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A total of three % of active substance is excreted in urine as unchanged Lively substance. Tapentadol is Also metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and to hydroxy tapentadol (2 %) by CYP2D6, that happen to be further more metabolised by conjugation. Therefore, active material metabolism mediated by cytochrome P450 progr